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1.
A feeling of intense regret and personal worthlessness after a night, weekend, week, month, or even year (possibly, but not always containing copious drunkenness/drug abuse) of moral turpitude.
"How was your weekend?"

"Oh, man, I got drunk, had sex with my friend's sister, crashed my dad's car, and told off my best friend. I've got a serious moral hangover."
by JLB3 August 15, 2005