an abbreviation of "Mother Fucker". it is used for slang.

(you mother fucker)
by Shana April 13, 2005
Indirect way of calling someone a Mother Fucker
Go away "Mo Fo"
You fo* "Mo Fo"(*fo meaning Fucking)
by Chris Lewis December 10, 2003
Mofo Meaning : motherfucker but in a word you can use around parents and or teachers!!Explaining someone who is a real annoyance and/or cocksucker and/or beotch
Stephanie:That Devon is a real mofo , I dump him and he says he dumped me !!

Nick:Yeah it's about time you dumped his sorry ass!!
by White-and-Nerdy January 05, 2007
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