It's an abbreviation for "Mother Fucker".
Guy - I fucked your mom.
Dude - You sick Mo-Fo!
by kane April 27, 2003
slang for " Mother Fucker '
by Preston November 07, 2002
Mother Fucker!!!!!!!!!!
Imma Kill You Mo Fo
by B-Law February 26, 2004
also known as Mother Fucker
Damnnn...he's one MOFO!
by AllenL March 16, 2007
an abbreviation of "Mother Fucker". it is used for slang.

(you mother fucker)
by Shana April 13, 2005
Indirect way of calling someone a Mother Fucker
Go away "Mo Fo"
You fo* "Mo Fo"(*fo meaning Fucking)
by Chris Lewis December 10, 2003
short for mother-fucker
"damn ur mums a mo-fo!"
by jon-T December 05, 2003
Mofo Meaning : motherfucker but in a word you can use around parents and or teachers!!Explaining someone who is a real annoyance and/or cocksucker and/or beotch
Stephanie:That Devon is a real mofo , I dump him and he says he dumped me !!

Nick:Yeah it's about time you dumped his sorry ass!!
by White-and-Nerdy January 05, 2007

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