short for "most definitely" (contrary to popular belief it is NOT mo def, and whoever said that is fucking retarded), used because saying most definitely sounds gay and mo defs sounds cool
Kid 1: dude that girl is so hot Kid 2: most definitely
Kid 1: wtf Kid 2: Uhh I mean mo defs
Kid 1: true dat
Kid 3: mo def
Kids 1 and 2: ...
Kid 1: shut up dumbass