A Man sister. A Metrosexual best friend, or someone whom you and your boys always hang out with and insist on inviting everywhere even though they act like a bitch half the time.
Dave - "Is Greg gay? Cause he is cool but kinda feminine."
Steven - "No he is our Mister"
Dave - "Your what..?"
Steven - "He is our man sister."
by yinnyolivo June 16, 2011
A nickname for the Toyota MR2.
I like my Mister because the frunk is awesome.
by Ian August 10, 2005

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