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1.
This term refers to an act whereby a young lady circumvents the loss of her viginity by practicing anal instead of vaginal intercourse. Its namesake refers to the compromise of 1820, whereby Missouri was excluded from inclusion as free state, even though it was above the Mason-Dixon line. Similarly, When a young lady finally is subject to vaginal intercourse, it is known as bleeding Kansas, which refers to the after effects of the Kansas-Nebraska act of 1854 which revoked the Missouri Compromise.
Frank's girlfriend wanted to keep her flower intact but frank needed release. Because her braces cut him too badly, they had to go with the Missouri compromise.
by Ricochet Jones August 19, 2006
 
2.
When during intercourse with a woman who wishes to maintain her vaginal virginity, anal sex is used as a substitute.
Shirley wasn't ready to lose her big V, so we pulled a Missouri Compromise.
by PopeGangstaNasty December 16, 2005
 
3.
When you kiss a girl who is chewing a type of tobacco much stronger than your own. Such as Skoal vs. Kodiak
Andrew: Yeah dude, I was makin' out with Carly last night and she gave me the Missouri compromise.
Chris: Bummer, what was she dippin?
Andrew: She was chewing a cope, grizzly mix.
Chris: I'm sorry bro, that's a bummer.
by CAGP June 20, 2010
 
4.
A mullet

See also Kentucky Waterfall.
Having just had his Missouri compromise trimmed, Enos Truffler decided to eat some leftover honey-baked ham sandwiches that his XXX porn star wife Portia Mercedes made for him the previous Sunday. He put all the fixings on it and washed it all down with a Mountain Dew. Then Enos read some of the newspaper and washed his truck. We're gonna miss him when he dies.
by Johnny Eightball June 10, 2004