Top Definition
The infamous 'headache, no sex' scenario we all encounter. The headache blocks any chances of a sexual encounter thus rendering the female genitals unapproachable hence the phrase 'mingegraine'.
“Fancy a pint tonight mate? Jane’s got another mingegraine.”

Or

“Everything was going swimmingly until Jane got a mingegraine.”
by Jacobson Flint August 06, 2009
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