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like every other kind of rot like crotchrot but with your head. Its when your up at 3 AM playing addicting games or reading celebrity twitters or watching terribly unintentionally hilarious pron. Basically, mindrot is doing something crushingly stupid while your mind slowly melts and all of your intelligence bleeds out of your ears.
Me- Yo, I was just so high, I decided to go on youtube and watch parkour accidents! Its was awesome but it was total fuckin mindrot.

My Friend- Dude you need a chick.

Me- Yeah real bad, fapping gets old.
mindrot by el hombre 123 June 27, 2009
Extremely dangerous drink unique to Miami of Ohio parties.
Dude I got mindprobed last night and woke up in total confusion and without my clothes or dignity
mindprobe by kelmastah October 3, 2008
A mythical creature which, according to legend, is frequently sighted near the Mindro-Ling Monastery near Lhasa in Tibet. It is revered in local culture where it is said to possess extraordinary powers of perception. It most often manifests itself as a sherpa, llama or liger and is routinely invoked by locals seeking guidance and wisdom in matters of right vs. wrong; good vs. evil.
Mindro appeared just in time to help me avoid a potentially tragic error in judgement.
Mindro by Nofrad Izgudfrad October 18, 2005

mindoosky 

Ammon: Man, i peed like 50 times last night.
Evan: Dude, you must have drank like a goliathan amount of mindoosky.
mindoosky by Anvex January 20, 2011
A failed social experiment testing how far people will go to gain insignificant amounts of power over the world.
This failed as badly as Mindoor did.

Mindrot, North Dakota 

This is a slang term for the city of Minot (a.k.a "Mindrot") North Dakota. Which is a very appropriate name considering the people who are born and raised in the town (and never leave) pretty much sit at home and watch tv 24/7 and literally allow their minds to rot. Funny what too much religion and limited exposure to the outside world can do to a person.
"Hi Steve, how are you? I haven't talked to you for along time! What? You're STILL living in Mindrot, North Dakota?! I'm sorry. What's the temp? -8 degrees? Geesh! Well I better let you go so you can go watch TV or go back to church."