Used to describe any action done soooooo earth-shatteringly epic, you'll be incappable of living a normal life afterwards.
2: That chick tits are so mindfuckingly gorgeous, I'd die a happy man if I got slapped in the face by one of them. Yeah, even just one.
3: Bitch, I was mindfuckingly drunk last night. What the FUCK did we drink?
What DIDN'T we drink???