It's a female noun (in italian every noun has a genre) but it's not the only example of italian that words describing genital organs while having the opposite grammatical genre.
General use, apart the litteral one, is - as for "cazzo" - to get sentence stronger as in english is done with fuck.
Used in the form "...sta minchia di..." (this minchia of)
means something not worth or definitively shitty or actually boring
The variation "Minchione" (literally "big minchia") is used to refer to somebody really dumb
"I've got a huge minchia"
"what the fuck you want?!"
"che minchia vuoi?!"
"suca la minchia, scemo"
"this minchia of car wont never go again"
"Sei proprio un minchione"
"You're truly dumb"
It means "penis" but in a female way, it is strange since "penis" in Italian is most defiantly masculine.
this can show the nice approach of the Sicilian people to sex organs.