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1.
A really tough course or other brain-torturing exercise, eg programming, advanced calculus or effective ventriloquism. Symptoms include poverty due to the rising cost of Advil and long hours crying and asking "Why the hell did I enroll in this?" to random strangers on the street.
Example 1

Tom: There goes Luke again. Ever since he went into advanced computer programming, he's been literally insane.

Jerry: Yeah, that course is a migraine farmer all right.

Example 2

Man, ever since I started trying to imitate Jeff Dunham, I've realized how much of a migraine farmer ventriloquism is! How does he do it?
by ABeefyRhino November 16, 2009