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a medicine only for girls
some call it the pms medicine
it relieves menstrual symptoms
girls love it
Dude get me my midol before i freaking rip your head off
midol by napoleon d May 17, 2005

American Midol 

The act of sitting your wife/girlfriend in front of the hit tv show "American Idol" for an uninterrupted hour of not being bitched at. The cable version of the pms medication, Midol.
Dude i gave my wife some american midol last night and i didn't have to talk or listen to her for an hour, it was better then sex
American Midol by Dylan684 August 11, 2010

Take a Midol 

"Take a Midol" is a disparaging phrase said to a woman who is behaving in a bitchy and confrontational fashion, as women are know to do when experiencing the symptoms of PMS. Sometimes said by a male, the phrase is more powerful when uttered by a female toward another female, as a strong complaint about the woman's behavior and/or attitude. (Midol is a commonly used over-the-counter medication marketed to women for the symptoms of PMS.)
Woman to woman: What is wrong with you? Stop being so upset and take a Midol!

Man to woman: Honey, please! Take a Midol before we have another domestic violence event in this house trailer!
Take a Midol by Rook's Buddy June 3, 2010
You're a total midolo!
midolo by UrbanLegend71 March 29, 2011
1.)a miracle pill or all them bitches who are pms-ing...
2.)something you tell a guy to take when he is being a straight-up ass hole.
3.) something you wrap up and give to a girl who is a total bitch to show her how much of a bitch she is.
1.) crap, i havnt taken my midol yet, dont make me kill you!
2.)(to a guy) what the hell is your problem? take some midol, man. damn.
3.)have some midol you phsycotic bitch!
Midol by Shubalaskubba April 17, 2006
A woman's happy pill. She takes during her period, and the physical transformation from raving bitch-beast to human is simply astounding.
On-Period Woman: *random raving understood only by other menstruating bitch-beasts* *takes Midol* And now I'm human again! Thanks, Midol!
Midol by tenderlumpling August 2, 2008