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1.
When someone does methanphetimines so long they don't know how to behave in society. The drunk meth cook violating probation that kills a young man while she was talking on her cell phone hooking up her next victim, while driving thru town.! A destructive drug user.
"That woman was f'n methed up"!
by JeannieHotPants March 04, 2008
 
2.
to be on meth while under the disco ball at cheap skate.
I'd choose to be methed up over the prostitutes at the front door any day
by guesshowmanysticks April 20, 2011