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2.
The gene that is passed down by blacks that makes their people naturally violent and mean.
Mean Black: I'm a mean black with a tennis racket! You gonna get raped!

White Woman: Oh great, his mean gene is acting up.
by Margie Corder September 23, 2009
 
1.
noun: a bout of diarrhea that comes on so quickly and ferociously that one would stop at any location with a working toilet- even a Mean Gene restaurant in the middle of West Virginia.

also used to describe any horrible fecal experience
I hope that aint a mean gene comin' on because we are miles from toilet paper.

Damn dude, I just dropped a mean gene that almost made me cry.
by Chester NoSeeds January 21, 2006