noun: a bout of diarrhea that comes on so quickly and ferociously that one would stop at any location with a working toilet- even a Mean Gene restaurant in the middle of West Virginia.
also used to describe any horrible fecal experience
I hope that aint a mean gene comin' on because we are miles from toilet paper.
Damn dude, I just dropped a mean gene that almost made me cry.
The gene that is passed down by blacks that makes their people naturally violent and mean.
Mean Black: I'm a mean black with a tennis racket! You gonna get raped!
White Woman: Oh great, his mean gene is acting up.