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1.
noun: a bout of diarrhea that comes on so quickly and ferociously that one would stop at any location with a working toilet- even a Mean Gene restaurant in the middle of West Virginia.

also used to describe any horrible fecal experience
I hope that aint a mean gene comin' on because we are miles from toilet paper.

Damn dude, I just dropped a mean gene that almost made me cry.
by Chester NoSeeds January 21, 2006
 
2.
The gene that is passed down by blacks that makes their people naturally violent and mean.
Mean Black: I'm a mean black with a tennis racket! You gonna get raped!

White Woman: Oh great, his mean gene is acting up.
by Margie Corder September 23, 2009