1. a (noun) meaning a man with an overwhelming desire to have an extreme amount of sex. mayos are known to be very well indowed and make excellent boyfriends as well as lovers.
2. a (noun) mayo is a thick white substance, some people spread on sandwhiches. made from oil, eggs, vinegar and seasonings.
2."i want some mayo on my sandwhich please."
Mayo Resident: Yo, where else but Mayo cracker? I won it kicking some white son of a bitch's ass at beer pong while at the sickest party EVER.