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1.
As opposed to March Madness, March Sadness is the deep, depressing feeling that comes when your brackets are completely fucked up and your favorite team lost.
Guy #1: Dude, what's wrong with Brad?
Guy #2: Ohio St. lost last night- he's got a case of March Sadness.
by lykomgrachel! March 26, 2007
 
2.
The immediate post-game depression you get when your team gets knocked out of the NCAA Tournament.
"Why is Mark so down?"

"He's got March Sadness, Duke got destroyed in the first round again.."
by Tucker Cotter March 24, 2008
 
3.
if and when your team gets beaten out of the ncaa mens basketball tournament
after the sweet sixteen it was just march sadness for me.

by michael watt April 09, 2009