Top Definition
A man in a severely depressed state. Often goes hand in hand with being mano alono.
Steve : Is James coming out tonight?
John : No, he's been mano depressedo since he split up with Claire and says he's just going to sit in and drink himself unconcious with a bottle of vodka
by El Smsmeistre May 30, 2007
5 Words related to mano depressedo

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