2. Male orifice, typically the mouth but also could refer to the anus or butthole.
"Dude you want to keep your manhole covered or someone's gonna cap your ass."
Nick: Yea, her dumbass didn't know that a manhole was hot....
Darbi: haha yeah! The way she screamed made me want to pee my pants!
Nic: I don't know man, i stole your phone yesterday and was looking at those nude pics she sent you. To be honest, thats one manhole i wouldn't venture into.