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1.
Used in place of saying "Oh my gosh".
Also, used to say you're frustrated or disappointed. Or in
place of a sigh.
Sometimes used in it's shorter version, mano.
Someone cuts you of and you almost hit them- "Man o' livin', that was close!"

Wake up and you don't want to go to work-"mano, mano."
by Manolivin October 07, 2007