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1.
Slang term for something of big time, major, gigantic or huge proportions.
Hey baby, you got some major league hooters.
by JohnstonGuy June 20, 2005
 
2.
feces. crap. poop. bowel movement number 2.
Joe: Ah man i gotta take a major league!
Andy: You gotta league it?
by lizzynicz May 28, 2009