An extremely vulgar phrase in Italian. Putana means slut/whore/prostitute. The Madonna is Mary, the mother of Jesus. "Madonna" is sometimes translated as "mother of God."

If you say this phrase, you're basically calling Jesus's mom a whore.
Uomo 1: "Mia moglie è incinta da un altro uomo"
Uomo 2: "Putana Madonna! Crepi!"
by diovero August 17, 2007
Get the Putana Madonna mug.