an obese unkept female who is generally found in sweatpants, gets jealous over the hottie/honey dip in the room that her man can't take his eyes off of, sometimes resulting in obvious bickering between the couple who leave the area shortly after the incident. Therefore she becomes a "mad cow" also known to be found happening with skinny ugly girls who have no boobs or personality and buck teeth, bug eyes , etc.
Madcow: has look of hate and eating chicken fried steak with mashed potatoes and gravy watching husband every eye movement and says nothing

Husband : can't control himself and incessantly stares while drooling at hotties taute firm ripe ass- leaves with raging hard on.

<mad cow > < Mad > <cow> <Madcow disease>

Honeydip to friend ; look! that Madcow and her man r leaving now
by Space cowgirl68 March 31, 2013
See Margaret Thatcher.
Oh no the mad cow is on the loose, get the tranquilzer gun!
by Brigante October 23, 2005
An STD received by striking out with a fat chick for quite some time
Beckeltron got mad cow
by Aflac March 23, 2004
When you don't treat a cow right. Meaning you don't yank on its tits.
Go yank on that mad cow's tits
by The clit commander April 10, 2003
A shot consisting of 1/2 Sperm, 1/4 Vodka, 1/4 Jack

You can tell someone its milk if you want to...
"Dude, Sherry just totally did a Mad Cow...shes so stupid.
by pool boy September 19, 2007
He gets more ass than a public toilet seat.
AoC CS2
by Anonymous July 02, 2003
When you are fucking a fat chick and you fuck a roll instead of her pussy, and she is angered when you shoot your load in her roll.
Emma was mad cowed when I couldn't find her twat under her rolls of flab.
by Madmike the Malevolent January 23, 2007

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