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1.
When you completely break down or lose control. Can be used positively or negatively.
"He tripped and fell into the pool and I totally lost my shit; I couldn't stop laughing."

"He tried to shove me and I lost my shit; I beat the hell out of him."
by WTFuchs November 30, 2011
 
2.
When one cannot keep control of oneself.
Prematurely Ejaculating
I tried to hold on, but I totally lost my shit!
by kneecapper December 18, 2006