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When one cannot keep control of oneself.
Prematurely Ejaculating
I tried to hold on, but I totally lost my shit!
by kneecapper December 18, 2006
When you completely break down or lose control. Can be used positively or negatively.
"He tripped and fell into the pool and I totally lost my shit; I couldn't stop laughing."

"He tried to shove me and I lost my shit; I beat the hell out of him."
by WTFuchs November 30, 2011