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1.
To start not caring about anything due to faliure in a certain area of your life:
Jack: Wow, have you seen Ed recently? He's got serious loser apathy since Adele.

Jill: Yea, always happens.
by Ed A October 12, 2004
 
2.
crazy ass bitch who laughs at the hanidcapped
*points and laughs at a cripple hitting a bus with his wheelchair
by Loser February 10, 2005