1-to lose one's mind; to become crazy or angry.
2-to miss the chance.
My dad's lost it!
A condition which happens to young men esp. after their girlfriends dump them, marked by a feeling of despair, depression and the inability to bond with another woman. Very common in men who get engagement rings returned. However, virtually unknown in divorsed men. Losing it could last several years if not longer.
After Tom got dumped which made him lose it, he spent the rest of his days watching the movie "Paris, Texas", over and over again.