The title is a Southern expression meaning at my wit's end.
When things are going so bad you could lose your faith.

Also a fabulous R.E.M. song.
Between the tight job market and my whiny kids I'm loosing my religion.
by pfeifferpack April 08, 2011
Best fucking black metal song ever. But only Graveworm's version, though.
I listened to Loosing my Religion over a dozen times last night.
by Paracetamol 500mg September 30, 2006

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