(verb expression) Short for locking the magazine/cartridge into the gun and loading the ammunition into the gun's chamber. (Usu. used to show toughness, ambition, fear and other strong characteristics. Originally spoken by John Wayne in "Sands of Iwo Jima" as "load and lock".)
One of the commandos in Resident Evil says "It's time to lock and load." when first seeing advancing zombies.
by Smkngmgc November 23, 2004
To adjust a woman's boobs into a high and central location on the chest and hold with a garment such as a vest or short jacket.
by DucRider October 31, 2007
When a female intentionally gets pregnant by her boyfriend, or a guy she's interested in to make sure that the guy is a part of her life forever, usually via marriage.
After David proposed, Nicole was bragging that they were only dating three months by the time she lock and loaded him.
by ParanoidPatsy June 10, 2009