-Little sister: Well I had to use SOMETHING to hang my teddy bear with!
-Big sister:AAAAAAAAAAAAAA AAAAAAAAAAAAAAA AAAAAAAAAAAAAAA AAAAAAAAAAAAAAA AAAAAAARRRRR RRRRRRRRRRGH!!! *hits little sister*
-Little sister: *bursts into tears* NORA HIT ME FOR NO REASON!!!
Now should you get your hands on a Little Sister (that is if you can get past their protectors the Big Daddies whom they refer to as Mr. Bubbles or Mr. B), you have a few options. You can save the little sister by killing the slug in her. This will turn her into a normal little girl, you will get whatever ADAM she has on her and she will be forever in your debt which can come to an advantage later. The second option is you can harvest her which will result in a maximum ADAM gain. This can lead to more plasmids and will make it easier for you to survive. She will not survive the process however.
Your final option can only be achieved if you are also a Big Daddy. You can adopt her and act as her protector. Bring her to the "Angels" and keep her safe while she gathers ADAM. She will then give you a portion of her ADAM and after two gathers you can choose to save or harvest.
Hurry Mr. B! Angels don't wait for slowpokes.
I can see angels!
Get him Mr. B!