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1.
When you feel nothin is goin your way.....and every moment feels like a struggle

Generally said before and after doing something really strenous and something you are just doin not out of choice.....

Q: Dude hows it goin??
A: Nothin man life is a bitch
Also used as a part of the phrase:
Life is a bitch, then you die!!!!!!!!!!
wait
Life is a bitch, you work overtime, then you die ;)!!!!!!!!!
by Ankit, Ashaesh, Goldyn September 25, 2006