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1.
Like when you wash your hair a second time in a row you get much more lather. The lather effect refers to when you get intoxicated a second night in a row, you get much more intoxicated.

"So remember, my friends, if you’re going to rinse and repeat always beware the extra bubbles." -- From the movie "The Lather Effect"
"I partied 3 days in a row, the lather effect was going strong."
by kerm|t January 02, 2012
5 1
 
2.
(n.) or (v.)
The effect of not being able to get drunk because of a high-state of trashedness the night before.

If you have been highly wasted one night, and try to get inebriated the next night it will cost you a fortune because it's nearly impossible.

The term comes from trying to lather a loufah, but it will not lather if there is still soap in it from the day before.
"I got so throwed on Thursday night there's no way I can get drunk tonight, you know...lather effect."

Dude 1: "You've had like 7 drinks and you're still a freakin intellect"

Dude 2: "Lather Effect, I had a crazy night last night."
by travi d. March 28, 2009
7 15