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1.
1) the worst case option
2) the course of action when all else fails
3) the final frontier
1) With the game on the line, Coach Peterson had no choice but to put their last resort, Rudy The Hunchback, on the field.
by John Bell November 25, 2005
 
2.
While at a social event, it is the guy/girl you know you can take home at the end of the night if you don't score with the girl/guy that you really want to hit. Usually of mediocre looks/intelligence/sex appeal.

The person with whom you will settle having sex with if your date decides 'I'm not that kind of girl/guy' and won't put out.
I was set to nail that MILF I met at the footbal game, but then her fuckin' kid sprained his ankle and couldn't spend the night at his friends house. I had to call that last resort slut on the skank block!
by No Way, Jose July 07, 2006
 
3.
When you really want to get high and You don't have a piece and no one in your group knows how to roll well and all you have is a Black and Mild. You cut the wooden filter off and proceed to loosen and empty the cigar without ripping it open. Then you hollow out the tip and place the hollow cigar into the tip. Finally you pack the weed into the cigar and twist off the end. Then all you gotta do is light and enjoy.

Caution: This rips extremely hard, I'd recommend bringing a drink.
My buddies and I couldn't stop coughing after that last resort.
by The botanist 420 December 20, 2011