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3.
The state of being on top of your game, i.e. livin large.
"How you livin, foo?"

"Large and in charge homeslice - I just got paid!"
by Jerry Tischleder June 10, 2008
45 60
 
1.
Obnoxious, overweight, and loud women, most frequently heard screaming at their small children over trivialities in public places (the grocery store, fast food restaurants, school events, etc.).
3 year old: “mom… look… dog snack”
Large and in charge: “KEEP YOUR HAND IN THE *^# SHOPPING CART BEFORE I KNOCK YOU INTO THE %&@ MEAT SECTION YOU LITTLE ^*(@!!!!
by workinglate April 01, 2005
502 88
 
2.
A combination of morbid obesity and obnoxious arrogance, more often middle to lower class females, especially black or hispanic, who hold strong beliefs that their weight is acceptable, healthy and attractive to the opposite sex.

In reality, these women are specifically localised in the United States of America, are often on welfare and have a reputation of producing numerous children in an attempt to abate society and prove they can have sexual intercourse with a male of the same species.

Most 'large and in charge' women who are caucasian have black babies.
Yolanda: I BE LARGE AND IN CHARGE NOW WHAYAH MAH BABY DADDY? (Note lack of ability to pluralise or utilise apostrophies in speech is eubonics.)
by Cunnilingius September 21, 2005
174 95
 
4.
The state of one's penis being large and/or in charge, possibly being so large that the person has sought medical help to amputate his leg and replace it with his penis.
Hey, How's the penis doing?
Large and in charge.
by A_LargeandInCharge_Guy July 31, 2011
10 27
 
5.
Generally a woman who is of larger than generally accepted weight, but is comfortable within her own skin. This kind of woman can be sexy inspite of her weight and often takes no shit. These women can be of any race, the only requirements is that they are "large", "Like Themselves as they are" and "Take no shit"
"Now that lady is large and in charge!"
by Ravenwolf B. February 27, 2006
82 106