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You don't know shit about fuck 

An extreme way to invalidate a person's opinion. It's a hardcore dis meant to bring the person it's directed at to complete silence.
Marven: This war is like fucking awesome yo!
Shanaynay: You don't know shit about fuck,asshole.
Marven:....................well damn.

you don't know shit from your asshole 

To be oblivious or uninformed on a subject you are trying to create a dialogue about.
The fact you think the government faked the moon landing proves you don't know shit from your asshole.

to know shit 

- a state of being
Being familiar with a topic or a broad range of topics. Either having extensive knowledge in a subject that your peers would consider you an expert, or having a firm grasp of a variety of topics that can summarize a wealth of practical knowledge.
You should listen to him, he really knows, his shit!
Trust me, I really know my shit.
This sentence is required to know shit.
to know shit by TheStylingDude March 10, 2016

This boy doesn't know shit about football mate 

When a stupid guy/girl doesn't know anything about football
Isaac-"CR7 is the GOAT of football"
Smart guy-"This boy doesn't know shit about football mate"

know your shit

To know your shit means you're really knowledgeable about a particular topic or field
Lindsay Lohan: I'm telling you the purity of this meth is 61%

Me: Wow, you really know your shit
know your shit by Ededdandeddy January 9, 2016

Do they know their shit 

Do they know their shit means have they mastered something, or do they know they're shit meaning their ignorance makes them worthless as an expert.
Do they know their shit or do they know they're shit?