Essentially means 'keep listening to this audio stream'.

Refers to locking your analogue radio to a particular station for extended listening, though in the modern day, it's more likely you're listening to a webcast or internet radio instead.
We've got the freshest beats from the underground just waiting to explode out of your soundsystems, so keep it locked (down (tight)).
by DarkIye December 30, 2011
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To tell someone to be safe and take care.
Bob: You out this weekend?
Bill: Nah mate, seeing the mrs!
Bob: Ok mate, well call me monday, see ya later and keep it locked!!

Bill: Aiiggghhht!!
by Mowgli-da-pimp October 31, 2007
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expression used on the radio show "weekly record check"
broadcasted on justqualitymusic.com
by Chicago dj and producer Pete Kazimierski.

Means stay tuned, keep listening, do not switch the channel.
Pete - "you're listening to the weekly record check on justqualitymusic.com, Keep it Locked!"
by jqminfo July 15, 2009
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Iconic tagline for community radio station RTRFM 92.1, frequently used by presenters during talk breaks. It encourages listeners to not touch the radio dial or turn off the audio stream when 'locked' on RTRFM.
Keep it locked to RTRFM 92.1, the Sound Alternative.
by artie77 May 19, 2022
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