1) Response to when someone says something overtly sexual.

2) It's a school night maybe she will keep it in her pants for once.

It's unisex. Ironic if said to a girl so completely fine.
similar to: "relax buddy, no need to get riled up there."
or
Person A- "DAYUM...the things I would do to that ass."

Person B- "Buddy, keep it in your pants."
by prophyte May 01, 2008

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