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1.
To be extremely intoxicated from copious amounts of alcohol.
Person 1: "Do you remember anything that happened last night?"
Person 2: "Nah, nothing. I was totally karened outta my mind."

Coworker 1: "Why is Jill sleeping on top of the fax machine?"
Coworker 2: "Oh, don't mind her. she's probably still karened from last night"
by Ktothe May 21, 2010