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1.
Used in the popular japanese anime series' called Dragonball, Dragonball Z and Dragonball GT. Actually called the "Kamehameha" rather than the "kamehamea" as wrongly mentioned above. It is all linked together when spoken in a conversation for easier pronunciation. The term Kame Hame Ha means "turtle destuction beam" in Japanese since the person to master the attack was Master Roshi the turtle hermit.
An immensely powerful blue beam of energy used as a last resort in battle because of its potentially planet destroying power.
Featured users of this attack in all the Dragonball series' are, Goku (Kakarot), Gohan, Goten, Krillin, Yamcha, Master Roshi, Majin Buu and Cell.(American version names)
Derivitives of this attack are, "Final Kamehameha" when Goku and Vegeta fused (Final Flash and Kamehameha).
"Big Bang Kamehameha" used when Vegeta fused with Goku.
10-fold Kamehameha, Goku in the super saiyan 4 level uses this in DBGT.
"Foot kamehameha" Goku used this to fly into the air in DB
"Kamekameha" Goten mispronounced the actual name and the attack was unmastered.
"Kame...... Hame..........Haaaaaaaaaa! (obviously)
"kamehamea wave is incorrect"
by Somebody New September 21, 2005
 
2.
For all you stupid assholes who call this the "Kamehameha", this is the real term. It is an energy blast in DBZ and is the pattented move of the "good guys", although Cell and Majin Bu have used it (and gotten their asses kicked for it). And so you know, it has nothing to do with a killer blow to the ass.
Kame....
by Batman March 05, 2003