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1.
Interjection. A stronger variation of jesus fucking christ. Used to express surprise or shock.
"Jesus titty fucking Christ!! That chick has a dick!"
by Dubious Skunk October 28, 2005
 
2.
Used - to great effect - by the boss in 'Team America - World Police.'
(Michael Moore enters)

"Jesus-titty-fucking-Christ!!!!"

(Ham flies everywhere)
by Sean Brian Kirby October 04, 2005
 
3.
A saying to show your astonishment, or to accent what you are saying. It can also be a totally random response to anything anyone says. It can also be to show disapproval.
YOUR GAY? JESUS TITTY FUCKING CHRIST I had no idea
by HOLYCRAP March 17, 2005
 
4.
A term of extreme surprise that should be used sparingly, lest its impact lessen.
Did you see that really surprising thing? look over there..

Jesus tittyfucking christ! I wouldn't have seen that had you not pointed it out, thank you kind sir
by Bo bvo bo bo bo bob b October 22, 2007
 
5.
When the son of god consensually fucks the titties of another man named Christ in public.
Greggles: Jesus titty fucking christ!!! Jesus is titty fucking CHRIST!!!
by victor kung October 29, 2010