An online slang term commonly found in instant messaging meaning "I Suck" but not in an orally sexual manner in a screw up kind of way. It is common among American High Schoolers in NYC.
I screwed up that god dam math test on geometric proof so mother f'ing bad, isk so freakin bad Rob.
by Kevin O'. March 27, 2005
Adjective - used to describe immense sadness that cannot be put into words
Person 1: "omg my mum just died"
Person 2: "aww man, isk"
by EmmaandZainareawesome November 11, 2014

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