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1.
International school of creative shit. basically a madhouse for animals and cows. bitches bite and dudes drool.
'oh you go to iscs?'
'yeah, they have really nice bathrooms in there.'
by your nice ass January 20, 2013
 
2.
ISC
Orginating on the Pies For Slippers forums, (www.piesforslippers.tk) it is an acronym for Internet Street Cred.
Her ISC is a lot better than Petes
Petes ISC is teh uber sux0r
by Ice9 May 15, 2005
 
3.
ISC
ISC is a gang in Chicago Insane Spanish Cobras. They were around long before these mayates called Insane Southside Crips, damn nigga it must be hard out there in Denver!!!! The Cobras were big in Logan Square, Humboldt Park, Cicero, K-town (Division and Tripp) and Bucktown back in the day. They rep black and green and are the leader or the Insane Folks family, which includes Orchestra Albanies, Insane Deuces, 22 boys, Ashland Vikings, C-notes and maybe others. I'm str8 Cobra killa but these niggas will shoot if bothered.
Insane Spanish Cobra Polaco C rotz nigga!!!!!! ISCK
by D FolKKz April 26, 2008
 
4.
ISC
Insane Soutside Crips.A Gang Located in Denver,Co
Those ISC niggas is ruthless.
by Psyco Loc November 16, 2006