Irritable Male Syndrome 

Irritable Male Syndrome (IMS) is the male equivalent of the female hormone change during menstruation. Believe it or not but men's hormones change every month too, this results in mood swings similar to those women experience. Luckily it doesn't cause men to bleed through their pecker.

Michael is suffering from Irritable Male Syndrome a.k.a his man period.

Irritable Male Syndrome by SkinnedHamster August 5, 2015

Irritable Bitch Syndrome 

The persistently inflammatory condition of a bitchy person, resulting in poor absorption of positive experiences while they express frequent yet pointless bitchiness. Habitual of certain men and women.

The beautiful, sunny day at the pricey amusement park was a nightmare with her Irritable Bitch Syndrome flaring up every ten minutes.

Irritable Bitch Syndrome by JayKayOfToronto February 24, 2009

irrisputable

Absolutely, undeniably, incontestably, indisputably, definitely, incontrovertibly, totally, irrefutably, positively, to the nth power, no way that any other outcome could have conceivably happened.

"Turns oit i had irrisputable proof i was out of the country."

irrisputable by Woofie August 26, 2012

irresistable 

someone that u cant take your eyes off off and you are drawn to and someone who is oober cute

david k is sooooo irresistable! i just cant get enough of him

irresistable by courtney h. December 16, 2006

Irritable Jowel Syndrome

A chronic disease suffered by a good friend of mine. Symptoms include yakking it up when he should be keeping his pie-hole shut.

Ken:Hey Norm, remember the time you, me & the 3 Mormon chicks....
Norm: Hey Ken, STFU! My wife's right here and doesn't need to hear about how I banged that Morman every day for 2 straight months in a row! You f*ing have irritable jowel syndrome, dude~~

Irritable Jowel Syndrome by Bangboy December 26, 2009

irritable 

Easily annoyed or angered. Cranky or grumpy. Cross, bad-tempered.

Sarah Good was called to testify. The irritable beggar rarely went to church and often muttered under her breath when she was denied food or shelter; she was an easy target for accusations of witchcraft.

irritable by Lorelili August 6, 2011

Irritable Fowl Syndrome 

An unhealthy obsession with the iPhone game Angry Birds. The disease is named as such because "irritable fowl" has a meaning similar to that of "angry bird."

Boss: "Hey Joe, would you mind stepping into my office? I think we need to have a little talk."
Joe: "Sure, what is it?"
Boss: "That was your third half-hour trip to the bathroom today and it's only 1:30. What's going on?"
Joe: "Unfortunately I suffer from Irritable Bowel Syndrome. We had chili for dinner last night, and it really hasn't been sitting well with me today."
Boss: "Hmm...well I asked some of your coworkers about it and they mentioned hearing sounds of chirps and snorts coming from one of the stalls on several occasions. It's Irritable Fowl Syndrome you're really suffering from, isn't it?"
Joe: "All right, I admit it! I can't stop playing Angry Birds!"
Boss: "Well lucky for you, you'll have plenty of time to chase those golden eggs during your unemployment!"

Irritable Fowl Syndrome by Nicholas D December 11, 2010