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25.
A word created by ignorant pricks who couldn't manage the time to learn the English language. Suspected to originate around the early 1900s on Angel Island, where many Asian immigrants lacked proper English.

Irregardless means exactly the same thing as regardless, regardless of its negativity.

See Regardless
Asian Immigrant: Irregardless, I do what (I)want!
by Ready-Liver May 07, 2009
 
22.
Since "regardLESS" means "WITHOUT regard" (ie "no matter what"), then "IRregardless" must mean "WITH regard" (ie "if that's okay").
HUSBAND: I'm going bowling with the guys tonight.

WIFE: No you're not; it's my mother's birthday; we're taking her out to dinner tonight.

HUSBAND: Well, I'm going bowling IRREGARDLESS.

WIFE: No! You will do what I say, or you won't get any for a month!

HUSBAND: What should I wear?

by Shelly Bozdog December 20, 2006
 
23.
Adverb
1. "without lack of regard" or "not without regard"

Adjective
1. "not disregardful"

While many claim it to be grammatically incorrect and brush it off as the dumb way of saying "regardless", there is a meaningful place for this word in the English language. The unreduced double negative formed by the prefix and affix acts as a redundant intensifier of the root word "regard"; meaning this word is useful in certain circumstances for emphasizing the sheer amount of regard or the mere presence of regard in a given situation. It is similar to the usage of superlative reflexive pronouns.
1. Irregardless of the anonymous tip, we decided to double the amount of guards.

2. The irregardless lifeguard noticed the drowning boy quickly.

3. I, myself, typed this irregardless of the lack of a sufficiently adequate definition.
by Lexicon Man February 13, 2008
 
24.
This is a word used by stupid American's. They mix words together in much the same way as you see their rather poorly educated President, Mr Bush, make up words on the spur of the moment.

If you examine any sentence where someone uses the word "irregardless" and you replace it with the word "regardless" then the sentence means exactly the same thing.

It is therefore a totally superfluous word and is actually a fanastic way of spotting a dumb-ass. Another word that help you spot a dumb-ass is supposebly (where the actual word is supposedly). There are many other examples :) used mostly by dumb Americans.
Irregarless of what you think, irregarless is a real word.

No! Regardless of what you think, it ain't!!
by M'Lud August 10, 2005
 
26.
Without lack of disregard.
Joey: Irregardless, she's a batch.
Beth: Irregardless isn't even a word.
Joey: Yes, it is. It means without lack of disregard.
by Mose September 30, 2005