Most commonly used in a sexual reference.
When a comment or joke can be taken sexually, or as a sexual innuendo.
"Stop with the insinuendos!"
An example of an insinuendo:
"Ooh! Do me next!"
to insinuate with a splash of innuendo
John: Oh really, where you heading
Jane: Either my place or yours
John: Oh, how do you know where i live?
Jane: I thought you could show me
(obviously, John isn't picking up on the insinuendo that Jane is putting forward)