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1.
Hitting all the bases and scoring on your first try.
Eric: I planned on getting to second base, but instead, I made an in-the-park homerun last night!

Parker: Fuckin' sweet bro!
by Errk XTC September 17, 2008
 
2.
When a guy is really quick in bed
or
When you should only be getting to third base, but based on your skill, luck or some mistake, you get laid.
Girl: Wow, 5 seconds. Is that it?
Boy: Yeah, in the park home run. Sorry.
or
Wow, I totally wasn't expecting to get laid.
by jc baby1 November 09, 2008