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2.
With knowledge of something.
"People in the know are aware of a nuclear explosion if even the slightest jolt was made upon the renegade carrier."
-part of the storyline for Blast Corps
by Dave October 21, 2004
 
1.
To know all of what is happening at any given time; to have a lot of friends and connections.
"Yo man, I'm bored.. anything going on tonight?"
"Why don't you call James? He's in the know."

"I gotta find someone in the know, so I can pick up some weight and get my business off the ground."
by JRS April 29, 2004
 
3.
1)to have intimate knowledge of a particular subject not necessarily every subject.

2)to be privy to uncommon knowledge

you know who Gwyneth is dating?

ask Rita she's in the know
by i heart your mom March 31, 2006