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1.
A condition of detachment or separation caused by using an iPod with headphones; being cut off or separated from others, despite their immediate presence, because the volume on iPod headphones is too loud.
My friend was trying to talk to me at the gym but I did not know because I was in iSolation.
by Ja$on June 16, 2007
 
2.
Physical isolation=being away from any human beings to a point of madness


Mental isolation=being in a place full of the oppisote IQ
physical isolation=being put in a psyco hospital and then hanging yourself

mental isolation=being in a room full of dumb asses
by Nick D. Wolf October 25, 2008
 
3.
In poker, a technique in which a player reraises a weaker player's bet, trying to play him heads-up (one on one) by making it expensive for any other players to call.
Bruce Lee: LaVar Arrington used isolation on Warren Sapp and forced Urlacher, Shaq and Busta Rhymes to fold.
Jose Contreras: LaVar is a fucking monster at poker, I'd never sit down with him.
by benny b from the bronx February 22, 2005
 
4.
A drinking game perfected in the East Coast of Canada that combines solitary confinement with liquor. Every participant must drink a handle of hard liquor in 45 minutes while isolated in their own personal room or confined space without any human interaction or communication. (Including cell phones, television, or even talking). The last person to finish their handle loses the game.
"We played Isolation last night.... It got fucking sloppy"
by dc15 October 24, 2009