the MIT version: to be completely mentally and physically exhausted from completing some form of academic work typically within the last 8 hours of it being due.
Man I am hosed, I stayed up all night finishing a pset.
Screwed.
in the 'Dude. You're screwed.' sense.
Sometimes also means Stuck.
"You did what?! Hosed, man.
"When you wish upon a falling star, your dreams can come true. Unless it's really a meteorite hurtling to the earth which will destroy all life. Then you're pretty much hosed no matter what you wish for. Unless it's death by meteor."