short for hop off them, them being my nuts
Telling someone to hop off em means to "get off my back" or "stop being annoying"
Could be used after completing the task that person was annoying you about
-Mom: Tommy can you PLEASE clean your room? I've asked you a million times
-Tommy: yeah mom maybe if you would just hop off em for a second
-Jason: yo dawg what did you get on your history tizzzest?
-Harry: 86, you?
-Jason: ooooooooo 93 bitch, hop off em
-Harry: nobody likes you